Lipid Metabolism Disorder in Cerebrospinal Fluid Related to Parkinson’s Disease

Background: Abnormal accumulation of lipids is found in dopamine neurons and resident microglia the substantia nigra patients with Parkinson’s disease (PD). The an important risk factor for PD. Previous studies have mainly focussed on lipid metabolism peripheral blood, but little attention has been given to cerebrospinal fluid (CSF). We drew lipidomic signature CSF from PD evaluated role as biomarkers diagnosis. Methods: Based approaches, we investigated compared healthy controls without dyslipidaemia blood explored relationship between serum by Pearson correlation analysis. Results: A total 231 species were detected classified into 13 families CSF. families, including phosphatidylcholine (PC), sphingomyelin (SM) cholesterol ester (CE), had significantly increased expression control. Hierarchical clustering was performed distinguish based changed 34 species. Unsupervised supervised methods used refine this classification. 12 species, 3-hydroxy-dodecanoyl-carnitine, Cer(d18:1/24:1), CE(20:4), CE(22:6), PC(14:0/18:2), PC(O-18:3/20:2), PC(O-20:2/24:3), SM(d18:0/16:0), SM(d18:2/14:0), SM(d18:2/24:1), SM(d18:1/20:1) SM(d18:1/12:0), selected draw Correlation analysis showed that CE family (22:6) a positive association not controls. Conclusions: Our results revealed may be considered potential biomarker diagnosis, CE, PC SM reveal pathological changes patients, such blood–brain barrier leakage.